INTRAVENOUS IMMUNOGLOBULIN TO TREAT NEONATAL SEPSIS: 16

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Intravenous immunoglobulin to treat neonatal alloimmune haemolytic disease.

OBJECTIVE To compare the efficacy of intravenous immunoglobulin (IVIg) and exchange transfusion (EXT) on rhesus haemolytic disease of the newborn (Rh-HDN) and evaluate treatment-related side effects. METHODS Retrospective chart review of two cohorts of newborns with Rh-HDN, treated with (Group 2) or without (Group 1) IVIg. Length of phototherapy, number of EXT, IVIg infusions, intrauterine an...

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Intravenous immunoglobulin for prophylaxis of neonatal sepsis in premature infants.

The incidence of sepsis, mortality due to sepsis, total mortality, and minor infections was evaluated in a group of 46 premature newborn infants who were treated with intravenous immunoglobulins. They were compared with an untreated control group. No significant differences were observed between the two groups.

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Children find a rectal examination unpleasant and over a third experienced severe discomfort in this study. This is acceptable only if essential information affecting management is obtained. In this series, the diagnosis of acute appendicitis in over 90% of cases was made from the clinical history and abdominal examination. In two cases the rectal tenderness indicated the correct diagnosis. Rec...

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Intravenous immunoglobulin for treating sepsis, severe sepsis and septic shock.

BACKGROUND Mortality from sepsis and septic shock remains high. Results of trials on intravenous immunoglobulins (IVIG) as adjunctive therapy for sepsis have been conflicting. This is an update of a Cochrane review that was originally published in 1999 and updated in 2002 and 2010. OBJECTIVES To estimate the effects of IVIG as adjunctive therapy in patients with bacterial sepsis or septic sho...

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Adjuvant high dose IVIgs are being used increasingly in a range of immune-mediated and auto-immune diseases. Although numerous immunomodulatory mechanisms have been suggested, the exact mechanisms of action are poorly understood. The efficacy of IVIg in certain diseases has been proven in clinical trials, in so far as IVIg is approved as the therapy of choice for Kawasaki syndrome and idiopathi...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1997

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-199705000-00035